Abstract
The functional status indicator for vitamin D, for both safety and efficacy, is serum 25-hydroxyvitamin D concentration. Efficacy for several health endpoints requires levels of 80 nmol/L or higher. Toxicity occurs at levels of 500 nmol/L or higher. The input needed for efficacy, in addition to typical food and cutaneous inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day).
MeSH terms
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Bone Density Conservation Agents / administration & dosage
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Bone Density Conservation Agents / adverse effects
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Bone Density Conservation Agents / pharmacokinetics
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Diet*
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Dietary Supplements / adverse effects
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Dietary Supplements / statistics & numerical data
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Dose-Response Relationship, Drug
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Humans
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Metabolic Clearance Rate / physiology*
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Risk Factors
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Safety
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Toxicology
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Vitamin D / administration & dosage
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Vitamin D / adverse effects
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Vitamin D / analogs & derivatives*
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Vitamin D / blood
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Vitamin D / pharmacokinetics
Substances
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Bone Density Conservation Agents
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Vitamin D
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25-hydroxyvitamin D