Effect of passive smoking on ciliary regeneration of nasal mucosa after functional endoscopic sinus surgery in children

J Laryngol Otol. 2009 Jan;123(1):75-9. doi: 10.1017/S0022215108003678. Epub 2008 Oct 10.


Hypothesis and background: Passive smoking in the paediatric age group is associated with an increased frequency of a number of childhood respiratory disorders. However, its effect on ciliary regeneration after functional endoscopic sinus surgery for chronic sinusitis has not previously been reported.

Material and methods: We conducted a prospective, nonrandomised cohort study on 38 paediatric patients with chronic sinusitis. We compared two patient groups--passive smokers and those not subjected to passive smoking--as regards ciliary regeneration after functional endoscopic sinus surgery, using objective methodology.

Results and conclusion: We found passive smoking to have a negative impact on sinus cilia regeneration following functional endoscopic sinus surgery.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Chronic Disease
  • Cilia / physiology
  • Cilia / ultrastructure
  • Cohort Studies
  • Endoscopy
  • Female
  • Humans
  • Male
  • Microscopy, Electron
  • Nasal Mucosa / physiology*
  • Nasal Mucosa / surgery
  • Nasal Mucosa / ultrastructure
  • Prospective Studies
  • Regeneration / physiology*
  • Sinusitis / surgery*
  • Tobacco Smoke Pollution / adverse effects*


  • Tobacco Smoke Pollution