Admixture as the basis for genetic mapping

Trends Ecol Evol. 2008 Dec;23(12):686-94. doi: 10.1016/j.tree.2008.07.008. Epub 2008 Oct 8.

Abstract

Genetic mapping in natural populations is increasing rapidly in feasibility and accessibility. As with many areas in genetics, advances in molecular techniques and statistics are drastically altering how we can investigate inheritance in wild organisms. For ecology and evolution, this is particularly significant and promising, because many of the organisms of interest are not amenable to conventional genetic approaches. Admixture mapping falls within a family of statistical approaches that use natural recombination and linkage disequilibrium between genetic markers and phenotypes as the basis for mapping. Our aim in this review is to provide a snapshot of previous and ongoing research, existing methods and challenges, the nature of questions that can be investigated and prospects for the future of admixture mapping.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Evolution
  • Chromosome Mapping*
  • Ecology
  • Genetic Markers*
  • Genetics, Population
  • Genome
  • Hybridization, Genetic*

Substances

  • Genetic Markers