The effects of IL-6 on CD4 T cell responses

Clin Immunol. 2009 Jan;130(1):27-33. doi: 10.1016/j.clim.2008.08.018. Epub 2008 Oct 8.


Cytokines have long been known to profoundly influence the adaptive immune response by determining CD4 T cell differentiation. Although IL-6 has been initially characterized as a B cell growth factor and inducer of antibody production research from our lab and others has revealed over the last years that IL-6 also plays a significant role in CD4 T cell differentiation. This review highlights the variety of ways in which IL-6 affects CD4 effector functions and how this may contribute to different types of diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / cytology
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • Cell Differentiation / immunology
  • Cell Survival
  • Humans
  • Interleukin-6 / immunology*
  • Receptors, Interleukin-6 / immunology
  • Signal Transduction / immunology


  • Interleukin-6
  • Receptors, Interleukin-6