Rat CINC, a member of the interleukin-8 family, is a neutrophil-specific chemoattractant in vivo

Exp Mol Pathol. 1991 Aug;55(1):30-7. doi: 10.1016/0014-4800(91)90016-q.


Rat cytokine-induced neutrophil chemoattractant (CINC) is a member of the IL-8 family and its human counterpart is MGSA/gro. Rat neutrophil responses in vitro to rat CINC, human IL-8, and human MGSA/gro were studied. CINC concentrations as low as 1 nM induced apparent chemotaxis of rat neutrophils, but human IL-8 and MGSA/gro required concentrations one or two orders higher than that of CINC to attract neutrophils. These data indicate that human IL-8 and MGSA/gro cannot sufficiently substitute for rat counterparts such as CINC in rats. Therefore, the effect of rat CINC on rats was studied. Intradermally injected 10(-10)-10(-7) M CINC dose-dependently caused infiltration of neutrophils. Significant migration of neutrophils appeared by 30 min, and maximum infiltration was observed around 1-2 hr after the injection. CINC induced quick and transient neutrophil accumulation without lymphocyte and monocyte migration or edema formation. CINC, a member of the IL-8 family but a counterpart of human MGSA/gro-related proteins, is a specific neutrophil chemoattractant and can be distinguished from IL-8, which is a chemotactic factor for lymphocytes and neutrophils.

MeSH terms

  • Animals
  • Cell Communication / drug effects
  • Cell Communication / physiology
  • Cell Membrane / drug effects
  • Cell Membrane / physiology
  • Chemokine CXCL1
  • Chemokines, CXC*
  • Chemotactic Factors / physiology*
  • Chemotaxis / drug effects
  • Chemotaxis / physiology*
  • Dose-Response Relationship, Drug
  • Growth Substances / physiology*
  • Intercellular Signaling Peptides and Proteins*
  • Interleukin-8 / physiology*
  • Lymphocytes / physiology
  • Male
  • Monocytes / physiology
  • Neutrophils / physiology*
  • Rats
  • Rats, Inbred Strains


  • CXCL1 protein, human
  • Chemokine CXCL1
  • Chemokines, CXC
  • Chemotactic Factors
  • Cxcl1 protein, rat
  • Growth Substances
  • Intercellular Signaling Peptides and Proteins
  • Interleukin-8