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. Mar-Apr 1991;54(2):66-9.

[Pikamilon Pharmacokinetics in Animals]

[Article in Russian]
  • PMID: 1884802

[Pikamilon Pharmacokinetics in Animals]

[Article in Russian]
B F Dorofeev et al. Farmakol Toksikol. .


Pycamilon was shown to be rapidly absorbed in the blood (tmax = 0.23 h), to penetrate well through the blood-brain barrier and to be intensively uptaken by the animal organs and tissues and to be eliminated mainly in the urine (t1/2 = 0.51 h). The drug bioavailability at oral administration to mice is 21.9%, and to rats from 53 to 78.9% (according to the urinary excretion data).

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