[Pikamilon pharmacokinetics in animals]

Farmakol Toksikol. 1991 Mar-Apr;54(2):66-9.
[Article in Russian]

Abstract

Pycamilon was shown to be rapidly absorbed in the blood (tmax = 0.23 h), to penetrate well through the blood-brain barrier and to be intensively uptaken by the animal organs and tissues and to be eliminated mainly in the urine (t1/2 = 0.51 h). The drug bioavailability at oral administration to mice is 21.9%, and to rats from 53 to 78.9% (according to the urinary excretion data).

Publication types

  • English Abstract

MeSH terms

  • Analgesics / administration & dosage
  • Analgesics / analysis
  • Analgesics / pharmacokinetics*
  • Animals
  • Biological Availability
  • Carbon Radioisotopes
  • Dose-Response Relationship, Drug
  • Mice
  • Rats
  • Time Factors
  • Tissue Distribution
  • gamma-Aminobutyric Acid / administration & dosage
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / analysis
  • gamma-Aminobutyric Acid / pharmacokinetics

Substances

  • Analgesics
  • Carbon Radioisotopes
  • nicotinoyl-GABA
  • gamma-Aminobutyric Acid