Integrating co-morbid depression and chronic physical disease management: identifying and resolving failures in self-regulation

Clin Psychol Rev. 2008 Dec;28(8):1426-46. doi: 10.1016/j.cpr.2008.09.002. Epub 2008 Sep 9.


Research suggests that treatments for depression among individuals with chronic physical disease do not improve disease outcomes significantly, and chronic disease management programs do not necessarily improve mood. For individuals experiencing co-morbid depression and chronic physical disease, demands on the self-regulation system are compounded, leading to a rapid depletion of self-regulatory resources. Because disease and depression management are not integrated, patients lack the understanding needed to prioritize self-regulatory goals in a way that makes disease and depression management synergistic. A framework in which the management of co-morbidity is considered alongside the management of either condition alone offers benefits to researchers and practitioners and may help improve clinical outcomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptation, Psychological
  • Affect
  • Chronic Disease / psychology*
  • Chronic Disease / rehabilitation
  • Comorbidity
  • Culture
  • Depressive Disorder / psychology*
  • Depressive Disorder / rehabilitation
  • Disease Management*
  • Humans
  • Internal-External Control*
  • Patient Care Team
  • Randomized Controlled Trials as Topic
  • Sick Role
  • Social Adjustment