Male-pattern Baldness Susceptibility Locus at 20p11

Nat Genet. 2008 Nov;40(11):1282-4. doi: 10.1038/ng.255. Epub 2008 Oct 12.

Abstract

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alopecia / genetics*
  • Chromosomes, Human, Pair 20 / genetics*
  • Female
  • Genetic Predisposition to Disease*
  • Genome, Human / genetics
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics