Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Nov;40(11):1279-81.
doi: 10.1038/ng.228. Epub 2008 Oct 12.

Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11

Affiliations

Susceptibility Variants for Male-Pattern Baldness on Chromosome 20p11

Axel M Hillmer et al. Nat Genet. .

Abstract

We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.

Comment in

Similar articles

  • Androgenetic alopecia: a review.
    Lolli F, Pallotti F, Rossi A, Fortuna MC, Caro G, Lenzi A, Sansone A, Lombardo F. Lolli F, et al. Endocrine. 2017 Jul;57(1):9-17. doi: 10.1007/s12020-017-1280-y. Epub 2017 Mar 28. Endocrine. 2017. PMID: 28349362 Review.
  • Investigation of the male pattern baldness major genetic susceptibility loci AR/EDA2R and 20p11 in female pattern hair loss.
    Redler S, Brockschmidt FF, Tazi-Ahnini R, Drichel D, Birch MP, Dobson K, Giehl KA, Herms S, Refke M, Kluck N, Kruse R, Lutz G, Wolff H, Böhm M, Becker T, Nöthen MM, Messenger AG, Betz RC. Redler S, et al. Br J Dermatol. 2012 Jun;166(6):1314-8. doi: 10.1111/j.1365-2133.2012.10877.x. Br J Dermatol. 2012. PMID: 22309448
  • Combing the genome for the root cause of baldness.
    McLean WH. McLean WH. Nat Genet. 2008 Nov;40(11):1270-1. doi: 10.1038/ng1108-1270. Nat Genet. 2008. PMID: 18957981 No abstract available.
  • Male-pattern baldness susceptibility locus at 20p11.
    Richards JB, Yuan X, Geller F, Waterworth D, Bataille V, Glass D, Song K, Waeber G, Vollenweider P, Aben KK, Kiemeney LA, Walters B, Soranzo N, Thorsteinsdottir U, Kong A, Rafnar T, Deloukas P, Sulem P, Stefansson H, Stefansson K, Spector TD, Mooser V. Richards JB, et al. Nat Genet. 2008 Nov;40(11):1282-4. doi: 10.1038/ng.255. Epub 2008 Oct 12. Nat Genet. 2008. PMID: 18849991 Free PMC article.
  • The genetics of androgenetic alopecia.
    Ellis JA, Harrap SB. Ellis JA, et al. Clin Dermatol. 2001 Mar-Apr;19(2):149-54. doi: 10.1016/s0738-081x(00)00125-5. Clin Dermatol. 2001. PMID: 11397593 Review. No abstract available.
See all similar articles

Cited by 26 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback