Susceptibility variants for male-pattern baldness on chromosome 20p11

Nat Genet. 2008 Nov;40(11):1279-81. doi: 10.1038/ng.228. Epub 2008 Oct 12.


We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alopecia / genetics*
  • Chromosomes, Human, Pair 20 / genetics*
  • Female
  • Genetic Predisposition to Disease*
  • Genome, Human / genetics
  • Germany
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics