Secretion of antidiuretic hormone in children with obstructive sleep apnea-hypopnea syndrome

Acta Otolaryngol. 2009 Aug;129(8):867-71. doi: 10.1080/00016480802441762.


Conclusions: Obstructive sleep apnea-hypopnea syndrome (OSAHS) in children with hypoxemia might influence the nocturnal secretion of antidiuretic hormone (ADH) that is associated with polyuria, even nocturia.

Objective: The impact of OSAHS on the secretion levels of ADH was studied in pediatric patients with adenotonsillar hypertrophy.

Subjects and methods: Forty-eight children (28 with OSAHS, 20 as normal controls) were recruited in this study. Respiratory indexes of all subjects were monitored by polysomnography and 12-h urinary volume was recorded during sleep. Vein blood was sampled to detect the levels of ADH in serum using a radioimmunoassay technique, both before and after adenotonsillectomy.

Results: After surgery for OSAHS, the mean value of the apnea-hypopnea index (AHI) decreased (from 17.36±2.61 to 3.32±1.41, p<0.001), lowest arterial oxygen saturation (LSaO(2)) increased (from 78.34±13.44 to 95.35±6.24, p<0.001), urine volume (UV) in nocturnal 12 h reduced (from 492±90 to 332±56, p<0.001), and ADH level increased (from 63.08±35.15 to 83.10±21.05, p<0.05). The differences in UV and ADH between postoperative children and healthy controls were not statistically significant (both p>0.05).

MeSH terms

  • Adenoidectomy*
  • Case-Control Studies
  • Child
  • Female
  • Humans
  • Male
  • Nocturia
  • Polysomnography
  • Postoperative Period
  • Preoperative Period
  • Sleep Apnea, Obstructive / metabolism*
  • Sleep Apnea, Obstructive / physiopathology
  • Sleep Apnea, Obstructive / surgery
  • Tonsillectomy*
  • Treatment Outcome
  • Vasopressins / blood
  • Vasopressins / metabolism*


  • Vasopressins