Cytoplasmic signalling by the c-Abl tyrosine kinase in normal and cancer cells

Biol Cell. 2008 Nov;100(11):617-31. doi: 10.1042/BC20080020.


c-Abl is a non-receptor tyrosine kinase which is localized both in the nucleus and cytoplasm, and is involved in the regulation of cell growth, survival and morphogenesis. Although c-Abl nuclear function has been extensively studied, recent data also indicate an important role in cytoplasmic signalling through mitogenic and adhesive receptors. Here, we review the mechanisms by which growth factors promote cytoplasmic c-Abl activation and signalling and its function in the induction of DNA synthesis, changes in cell morphology and receptor endocytosis. The importance of de-regulated c-Abl cytoplasmic signalling in solid tumours is also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Transformation, Neoplastic / metabolism
  • Cytoplasm / chemistry
  • Cytoplasm / genetics
  • Cytoplasm / metabolism*
  • Gene Expression Regulation
  • Humans
  • Neoplasms / metabolism*
  • Neoplasms / physiopathology
  • Neoplasms / therapy
  • Protein Binding
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-abl / chemistry
  • Proto-Oncogene Proteins c-abl / genetics
  • Proto-Oncogene Proteins c-abl / metabolism*
  • Signal Transduction*


  • Proto-Oncogene Proteins c-abl