Preliminary results of femtosecond laser-assisted descemet stripping endothelial keratoplasty

Arch Ophthalmol. 2008 Oct;126(10):1351-6. doi: 10.1001/archopht.126.10.1351.


Objective: To evaluate the preliminary visual results of femtosecond laser-assisted Descemet stripping endothelial keratoplasty (FS-DSEK).

Methods: We prospectively analyzed results of 20 consecutive patients with Fuchs endothelial dystrophy or aphakic/pseudophakic bullous keratopathy who underwent FS-DSEK. Best spectacle-corrected visual acuity (BSCVA), refraction, corneal topography, and endothelial cell density were measured preoperatively and 3 and 6 months after FS-DSEK. Corneal thickness was measured using an optical coherence tomography technique.

Results: The average BSCVA of 11 eyes with normal visual potential significantly improved from 20/110 +/- 4 lines to 20/57 +/- 1 line at 6 months (P < .007). At 6 months, the mean (SD) hyperopic shift was 2.24 (2.3) diopters (D). Preoperative and 6 months postoperative refractive astigmatism were -0.75 (0.9) D and -1.58 (1.1) D (P = .01), but the topographic astigmatism did not change postoperatively (P = .95). Mean (SD) endothelial cell density at 6 months was 1368 (425) cells/mm(2). There was a persistent deswelling of the graft up to 3 months postoperatively. Complications included graft dislocations requiring repositioning (20%), pupillary block glaucoma (5%), epithelial ingrowth (5%), and primary graft failure (5%).

Conclusions: Femtosecond laser-assisted Descemet stripping endothelial keratoplasty was effective in treating endothelial failure with minimal induced refractive astigmatism, limited improvement of BSCVA, and induction of a hyperopic shift. Endothelial cell count and dislocation rate were significant, which may be related to the surgical technique.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Corneal Diseases / diagnosis
  • Corneal Diseases / surgery
  • Corneal Surgery, Laser / methods*
  • Corneal Transplantation / methods*
  • Descemet Membrane / surgery*
  • Endothelium, Corneal / surgery
  • Endothelium, Corneal / transplantation
  • Evaluation Studies as Topic
  • Female
  • Follow-Up Studies
  • Fuchs' Endothelial Dystrophy / diagnosis
  • Fuchs' Endothelial Dystrophy / surgery*
  • Graft Rejection
  • Graft Survival
  • Humans
  • Male
  • Middle Aged
  • Probability
  • Prospective Studies
  • Risk Assessment
  • Statistics, Nonparametric
  • Treatment Outcome
  • Visual Acuity