Metabolic syndrome: from epidemiology to systems biology

Nat Rev Genet. 2008 Nov;9(11):819-30. doi: 10.1038/nrg2468.


Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent models have provided important molecular insights. However, as yet, only a small fraction of the genetic component is known. Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn.

Publication types

  • Review

MeSH terms

  • Epigenesis, Genetic / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation*
  • Genomics / methods
  • Humans
  • Insulin Resistance / genetics*
  • Metabolic Syndrome / epidemiology*
  • Metabolic Syndrome / genetics*
  • Risk Factors
  • Sex Factors
  • Systems Biology / methods*