The effect of hydrolyzed Spirulina by malted barley on forced swimming test in ICR mice

Int J Neurosci. 2008 Nov;118(11):1523-33. doi: 10.1080/00207450802325603.


Spirulina is a true puree of a filamentous, spiral-shaped blue alga and exerts the useful properties as a source of many biochemicals. This study investigated the antidepressant-like effect of hydrolyzed Spirulina by malted barley on the forced swimming test in mice. After the forced swimming test, we examined the levels of several blood biochemical parameters in mice. The effect of the hydrolyzed Spirulina by malted barley-treated group for 2 weeks on the immobility time was significantly reduced in comparison with the control group (p < .05). Plasma level of blood urea nitrogen and lactate dehydrogenase was significantly decreased in the hydrolyzed Spirulina by malted barley-treated group compared with the control group (p < .05). It had no effect on the variation of creatine kinase, glucose, total protein, and albumin levels. Therefore, these results suggest that hydrolyzed Spirulina by malted barley might be a candidate among antidepressant agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidepressive Agents / chemistry
  • Antidepressive Agents / pharmacology*
  • Blood Urea Nitrogen
  • Brain / drug effects
  • Brain / metabolism
  • Cell Extracts / pharmacology*
  • Cell Extracts / therapeutic use
  • Depressive Disorder / blood
  • Depressive Disorder / drug therapy*
  • Hordeum / chemistry
  • Hordeum / metabolism
  • L-Lactate Dehydrogenase / blood
  • L-Lactate Dehydrogenase / drug effects
  • Mice
  • Mice, Inbred ICR
  • Motor Activity / drug effects*
  • Motor Activity / physiology
  • Spirulina / chemistry*
  • Swimming / psychology*
  • Treatment Outcome


  • Antidepressive Agents
  • Cell Extracts
  • L-Lactate Dehydrogenase