Effect of gluten-free diet on preventing recurrence of gastroesophageal reflux disease-related symptoms in adult celiac patients with nonerosive reflux disease

J Gastroenterol Hepatol. 2008 Sep;23(9):1368-72. doi: 10.1111/j.1440-1746.2008.05507.x.


Background and aim: In celiac disease (CD) the role of a gluten-free diet (GFD) on gastroesophageal reflux disease-related symptoms (GERD-rs) is unclear. The aim of this study was to establish the recurrence of GERD-rs, in CD patients with nonerosive reflux disease (NERD).

Methods: From a total of 105 adult CD patients observed, 29 who presented with the NERD form were enrolled in the study. Thirty non-CD patients with NERD were studied as controls. Recurrence of GERD-rs was clinically assessed at 6, 12, 18, and 24 months follow-up (FU) after withdrawal of initial proton-pump inhibitor (PPI) treatment for 8 weeks.

Results: GERD-rs were resolved in 25 (86.2%) CD patients and in 20 (66.7%) controls after 8 weeks of PPI treatment. In the CD group, recurrence of GERD-rs was found in five cases (20%) at 6 months but in none at 12, 18, and 24 months while in the control group recurrence was found in six of 20 controls (30%), in another six (12/20, 60%), in another three (15/20, 75%), and in another two (17/20, 85%) at 6, 12, 18, and 24 months FU respectively.

Conclusions: The present study is the first to have evaluated the effect of a GFD in the nonerosive form of GERD in CD patients, by means of clinical long-term follow-up, suggesting that GFD could be a useful approach in reducing GERD symptoms and in the prevention of recurrence.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Celiac Disease / complications
  • Celiac Disease / diet therapy*
  • Celiac Disease / drug therapy
  • Celiac Disease / pathology
  • Combined Modality Therapy
  • Diet, Gluten-Free*
  • Disease Progression
  • Esophagitis / etiology
  • Esophagitis / prevention & control
  • Esophagoscopy
  • Female
  • Gastroesophageal Reflux / etiology
  • Gastroesophageal Reflux / pathology
  • Gastroesophageal Reflux / prevention & control*
  • Heartburn / etiology
  • Heartburn / prevention & control
  • Humans
  • Male
  • Middle Aged
  • Proton Pump Inhibitors / therapeutic use
  • Secondary Prevention
  • Time Factors
  • Treatment Outcome
  • Young Adult


  • Proton Pump Inhibitors