OMA-gosh, where's that TAF?

Cell. 2008 Oct 3;135(1):18-20. doi: 10.1016/j.cell.2008.09.021.


How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition between maternal and zygotic gene expression.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans / embryology*
  • Caenorhabditis elegans / metabolism
  • Caenorhabditis elegans Proteins / metabolism*
  • Carrier Proteins / metabolism*
  • Gene Expression Regulation, Developmental
  • Gene Silencing*
  • Transcription Factors / metabolism*
  • Transcription, Genetic
  • Zygote / metabolism


  • Caenorhabditis elegans Proteins
  • Carrier Proteins
  • OMA-1 protein, C elegans
  • TAF-4 protein, C elegans
  • Transcription Factors
  • oma-2 protein, C elegans