Stressing the brain, fattening the body

Cell. 2008 Oct 3;135(1):20-2. doi: 10.1016/j.cell.2008.09.030.


Obesity is characterized by chronic activation of inflammatory pathways in peripheral tissues. In this issue, Zhang et al. (2008) demonstrate that inflammation also occurs in the central nervous system where it disrupts activity of the hypothalamus leading to resistance to leptin that is mediated by activation of IKK and the endoplasmic reticulum stress response.

Publication types

  • Comment

MeSH terms

  • Animals
  • Endoplasmic Reticulum / physiology
  • Humans
  • Hypothalamus / physiopathology*
  • I-kappa B Kinase / metabolism
  • Leptin / metabolism
  • Mice
  • Obesity / physiopathology*
  • Overnutrition / physiopathology*


  • Leptin
  • I-kappa B Kinase