Reappraisal of amoxycillin absorption kinetics

J Antimicrob Chemother. 1991 May;27(5):647-54. doi: 10.1093/jac/27.5.647.


Interest in the intestinal absorption mechanisms of drugs has increased because transepithelial passage across the gut does not necessarily follow a passive diffusion process. Amoxycillin, like other amino-beta-lactam antibiotics, has been demonstrated in vitro to use the dipeptide carrier-mediated system in rodent small intestine. In order to assess the in-vivo relevance of these data, we applied the Loo-Riegelman method for a reappraisal of amoxycillin absorption kinetics in healthy human volunteers. The results showed evidence of a saturable carrier-mediated uptake of this antibiotic. With respect to the in-vitro data previously published, the dipeptide carrier system would appear to be the most likely transport mechanism.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Amoxicillin / administration & dosage
  • Amoxicillin / blood
  • Amoxicillin / pharmacokinetics*
  • Biological Availability
  • Drug Carriers
  • Humans
  • Injections, Intravenous
  • Intestinal Absorption*
  • Male
  • Regression Analysis


  • Drug Carriers
  • Amoxicillin