[Fish oil supplementation in rheumatoid arthritis]

Reumatismo. Jul-Sep 2008;60(3):174-9. doi: 10.4081/reumatismo.2008.174.
[Article in Italian]


The beneficial properties of fish oil are well known and are related to its fatty acid composition rich in omega-3 polyunsaturated fatty acids. In the last years a variety of epidemiological and clinical studies have demonstrated the efficacy of fish oil supplementation in the rheumatic diseases, in particular in rheumatoid arthritis. The anti-inflammatory effects of fish oil are linked to the production of alternative eicosanoids, to the reduction of proinflammatory cytokines, to the inhibition of the activation of T lymphocytes and of catabolic enzymes. Fish oil supplementation could represent a valuable support to the traditional pharmacological treatment of rheumatoid arthritis.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / economics
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Arthritis, Rheumatoid / drug therapy*
  • Clinical Trials as Topic
  • Cyclosporine / pharmacokinetics
  • Dietary Supplements*
  • Drug Costs
  • Drug Interactions
  • Eicosapentaenoic Acid / pharmacology
  • Eicosapentaenoic Acid / therapeutic use
  • Fatty Acids, Unsaturated / pharmacology
  • Fatty Acids, Unsaturated / therapeutic use
  • Fish Oils / economics
  • Fish Oils / pharmacokinetics
  • Fish Oils / pharmacology
  • Fish Oils / therapeutic use*
  • Humans
  • Methotrexate / pharmacokinetics
  • Sulfasalazine / pharmacokinetics


  • Anti-Inflammatory Agents, Non-Steroidal
  • Fatty Acids, Unsaturated
  • Fish Oils
  • Sulfasalazine
  • Cyclosporine
  • Eicosapentaenoic Acid
  • docosapentaenoic acid
  • Methotrexate