Discovery of new therapeutic targets by the informational spectrum method

Curr Protein Pept Sci. 2008 Oct;9(5):493-506. doi: 10.2174/138920308785915245.


The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we review the application of the informational spectrum method (ISM), a virtual spectroscopy method for structure/function analysis of proteins, in identification of functional protein domains representing candidate therapeutic targets for drugs against human immunodeficiency virus (HIV)-1, anthrax, highly pathogenic influenza virus H5N1 and cardiovascular diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Anthrax / drug therapy
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use
  • Cardiovascular Diseases / drug therapy
  • Cardiovascular Diseases / genetics
  • Computational Biology / methods*
  • Drug Design*
  • Forecasting
  • HIV-1 / drug effects
  • Humans
  • Influenza A Virus, H5N1 Subtype / drug effects
  • Influenza A Virus, H5N1 Subtype / isolation & purification
  • Molecular Sequence Data
  • Mutation
  • Proteins / chemistry*
  • Proteins / metabolism
  • Risk Factors
  • Structure-Activity Relationship


  • Anti-HIV Agents
  • Proteins