[Chromosomal localization and molecular organization of human genomic fragment containing TNF/LT locus in transgenic mice]

Mol Biol (Mosk). 2008 Jul-Aug;42(4):629-38. doi: 10.1134/s0026893308040201.
[Article in Russian]


Molecular organization, copy number and chromosomal localization of human TNF/LT locus fragment were determined in genomes of two transgenic mouse lines. Genome of the first one contains two copies, organized in head-to-tail manner and determined on eighth chromosome by karyotyping; single transgene copy of the second line is observed on the fifth chromosome. These mice could serve as valuable model for studying both human tumor necrosis factor and lymphotoxin physiological functions.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosomes, Mammalian / genetics*
  • Gene Dosage / genetics
  • Humans
  • Lymphotoxin-alpha / genetics*
  • Mice
  • Mice, Transgenic
  • Mutagenesis, Insertional*
  • Quantitative Trait Loci / genetics*
  • Tumor Necrosis Factor-alpha / genetics*


  • Lymphotoxin-alpha
  • Tumor Necrosis Factor-alpha