Ki-67 and bromodeoxyuridine labeling of human choroidal melanoma cells

Curr Eye Res. 1991 May;10(5):479-84. doi: 10.3109/02713689109001755.


Understanding tumor growth patterns has implications for prognosis as well as for response and susceptibility to treatment. The antibody Ki-67 was used as a marker of cycling cells and bromodeoxyuridine (BrdUrd) was used as a marker of proliferating cells to characterize the cycling and proliferative rates of cells from human choroidal melanoma. The BrdUrd labeling indices varied from 0-1.1% and the Ki-67 labeling indices ranged from 0-3.0.3%. Linear regression modeling showed good correlation defined by the equation: Ki-67 index = 0.237 + 1.63 x BrdUrd labeling index with r = 0.919. Correlations between these indices and clinical and histologic parameters were not significant.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Monoclonal
  • Biomarkers, Tumor*
  • Bromodeoxyuridine*
  • Choroid Neoplasms / diagnosis*
  • Fluorescent Antibody Technique
  • Humans
  • Ki-67 Antigen
  • Melanoma / diagnosis*
  • Nuclear Proteins*
  • Tumor Cells, Cultured


  • Antibodies, Monoclonal
  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Nuclear Proteins
  • Bromodeoxyuridine