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Comparative Study
, 10 (3), 539-46

The Interleukin-6-dependent DNA-binding Protein Gene (Transcription Factor 5: TCF5) Maps to Human Chromosome 20 and Rat Chromosome 3, the IL6 Receptor Locus (IL6R) to Human Chromosome 1 and Rat Chromosome 2, and the Rat IL6 Gene to Rat Chromosome 4

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Comparative Study

The Interleukin-6-dependent DNA-binding Protein Gene (Transcription Factor 5: TCF5) Maps to Human Chromosome 20 and Rat Chromosome 3, the IL6 Receptor Locus (IL6R) to Human Chromosome 1 and Rat Chromosome 2, and the Rat IL6 Gene to Rat Chromosome 4

J Szpirer et al. Genomics.

Abstract

Using two panels of somatic cell hybrids segregating either human or rat chromosomes, the gene encoding the interleukin-6-dependent DNA-binding protein, also called liver activator protein (designated transcription factor 5: TCF5), was assigned to human chromosome 20 and to rat chromosome 3. The TCF5 gene might be identical with the NF-IL6 gene. The locus encoding the IL6 receptor gene (IL6R) was localized to human chromosome 1 and rat chromosome 2. An IL6R-like (IL6RL) locus was also assigned to human chromosome 9. In addition, the rat interleukin-6 (IL6) gene was assigned to rat chromosome 4. These mapping data allow one to extend comparison between the rat, mouse, and human gene maps.

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