Pheochromocytoma with pyrexia and marked inflammatory signs: a paraneoplastic syndrome with possible relation to interleukin-6 production

J Clin Endocrinol Metab. 1991 Oct;73(4):877-81. doi: 10.1210/jcem-73-4-877.


Pheochromocytoma can cause several paraneoplastic syndromes. We report a patient with pheochromocytoma who exhibited pyrexia and marked inflammatory signs along with an elevated serum interleukin-6 (IL-6) level. All of these abnormalities disappeared and serum IL-6 became undetectable by removal of the tumor. In addition, immunohistochemical analysis revealed the presence of IL-6 in the tumor cells. It is suggested that pyrexia and the elevation of acute phase proteins can be a paraneoplastic syndrome with pheochromocytoma, and that the elaboration of IL-6 from pheochromocytoma may play an important role in the development of the syndrome.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Gland Neoplasms / complications*
  • Adrenal Gland Neoplasms / metabolism
  • Adrenal Gland Neoplasms / pathology
  • Female
  • Fever / complications*
  • Fever / metabolism
  • Fever / pathology
  • Humans
  • Immunohistochemistry
  • Interleukin-6 / metabolism*
  • Interleukin-6 / physiology
  • Middle Aged
  • Paraneoplastic Syndromes / metabolism
  • Paraneoplastic Syndromes / pathology*
  • Pheochromocytoma / complications*
  • Pheochromocytoma / metabolism
  • Pheochromocytoma / pathology


  • Interleukin-6