Use of trabeculectomy with postoperative 5-fluorouracil in patients requiring extremely low intraocular pressure levels to limit further glaucoma progression

Ophthalmology. 1991 Jul;98(7):1047-52. doi: 10.1016/s0161-6420(91)32178-x.


The authors conducted a randomized, controlled clinical trial to quantify the effect of 5-fluorouracil (5-FU) on filtration surgery. Both eyes of 17 patients with either bilateral low-tension glaucoma or advanced chronic open-angle glaucoma that would be expected to progress at intraocular pressures in the normal range were included. One eye received a full-thickness filtering procedure with a modified shell tamponade technique, and the other received a trabeculectomy with postoperative 5-FU. Follow-up was equal for both eyes and averaged 9.2 months. In eyes in the shell group, the average postoperative pressure was 10.94 mmHg, and in the 5-FU group it was 6.94 mmHg, (P = 0.0001). However, the postoperative visual acuity decrease was significantly greater in the 5-FU group (P less than 0.05). Choroidal detachments also were more frequent in the 5-FU group, but this was not statistically significant.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Chronic Disease
  • Female
  • Fluorouracil / therapeutic use*
  • Follow-Up Studies
  • Glaucoma, Open-Angle / drug therapy
  • Glaucoma, Open-Angle / prevention & control
  • Glaucoma, Open-Angle / surgery*
  • Humans
  • Intraocular Pressure / drug effects*
  • Male
  • Middle Aged
  • Postoperative Care
  • Postoperative Complications
  • Trabeculectomy*
  • Visual Acuity / drug effects


  • Fluorouracil