A 2-substituted prodiginine, 2-(p-hydroxybenzyl)prodigiosin, from Pseudoalteromonas rubra

J Nat Prod. 2008 Nov;71(11):1970-2. doi: 10.1021/np800493p. Epub 2008 Oct 15.


In the course of work aimed at the discovery of new pharmaceutical lead compounds from marine bacteria, a lipophilic extract of the bacterium Pseudoalteromonas rubra displayed significant cytotoxicity against SKOV-3, a human ovarian adenocarcinoma cell line. Bioassay-directed fractionation of this extract resulted in the isolation of a series of known and new prodiginine-type azafulvenes. The structure of the major metabolite was elucidated by interpretation of spectroscopic data as a 2-substituted prodigiosin, which we named 2-(p-hydroxybenzyl)prodigiosin (HBPG).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Humans
  • Marine Biology
  • Molecular Structure
  • Prodigiosin* / analogs & derivatives
  • Prodigiosin* / chemistry
  • Prodigiosin* / metabolism
  • Pseudoalteromonas / chemistry*


  • 2-(p-hydroxybenzyl)prodigiosin
  • prodiginine
  • Prodigiosin