Lack of replication of association between GIGYF2 variants and Parkinson disease

Hum Mol Genet. 2009 Jan 15;18(2):341-6. doi: 10.1093/hmg/ddn340. Epub 2008 Oct 15.


Mutations in GIGYF2 have recently been described as causative of Parkinson's disease in Europeans. In an attempt to replicate these results in independent populations, we sequenced the entire coding region of GIGYF2 in a large series of Portuguese and North American samples. We report the finding of two of the previously published mutations in neurologically normal Control individuals. This suggests that mutations in GIGYF2 are not strongly related to the development of the disease in either of these populations.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Carrier Proteins / genetics*
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Parkinson Disease / epidemiology
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide
  • Portugal / epidemiology
  • Reproducibility of Results
  • United States / epidemiology


  • Carrier Proteins
  • GIGYF2 protein, human