Hip fracture risk and different gene polymorphisms in the Turkish population

Clinics (Sao Paulo). 2008 Oct;63(5):645-50. doi: 10.1590/s1807-59322008000500013.


Background: We aimed to discuss the risk assessments for both patients with hip fractures due to fall-related, low energy traumas and non-fractured control patients by examining bone mineral density and genetic data, two features associated with femoral strength and hip fracture risk.

Methods: Twenty-one osteoporotic patients with proximal femur fractures and non-fractured, osteoporotic, age- and gender-matched controls were included in the study. Bone mineral density measurements were performed with a Lunar DXA. The COL1A1, ESR, VDR, IL-6, and OPG genes were amplified, and labeling of specific gene sequences was performed in a multiplex polymerase chain reaction using the osteo/check PCR kit from the whole blood of all subjects.

Results: The bone mineral density (trochanteric and total bone mineral density values) of the fracture group was significantly decreased relative to the control group. We were not able to conduct statistical tests for the polymorphisms of the COL1A1, ESR, and VDR genes because our results were expressed in terms of frequency. Although they were not significant, we did examine differences in the IL-6 and OPG genes polymorphisms between the two groups. We concluded that increasing the number of cases will allow us to evaluate racial differences in femoral hip fracture risk by genotypes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon / methods
  • Accidental Falls
  • Aged
  • Bone Density / genetics*
  • Case-Control Studies
  • Collagen Type I / genetics*
  • Collagen Type I, alpha 1 Chain
  • Estrogen Receptor alpha / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Hip Fractures / diagnostic imaging
  • Hip Fractures / genetics*
  • Humans
  • Interleukin-6 / genetics*
  • Male
  • Osteoporosis / complications
  • Osteoporosis / diagnostic imaging
  • Osteoporosis / genetics
  • Osteoprotegerin / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic / genetics
  • Risk Assessment
  • Turkey


  • Collagen Type I
  • Collagen Type I, alpha 1 Chain
  • ESR1 protein, human
  • Estrogen Receptor alpha
  • Interleukin-6
  • Osteoprotegerin