Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon soft tissue sarcoma with evolving literature on its cytomorphological features and limited documentation of its molecular analysis. Herein, we present cytological features, including review, of four cases of an EMC. Smears were predominantly hypercellular, comprising tumor cells arranged in clusters, traberculae, and cords against a variable chondromyxoid background. Cells were mainly polygonal shaped with round to indented nuclei, uniform chromatin, displaying intranuclear inclusions, grooves, and eosinophilic to finely vacuolated cytoplasm. Three cases revealed presence of "rhabdoid" cells. All cases had histopathologic confirmation. One case displayed t(9;22)(q22;q12) translocation by fluorescent in situ hybridization (FISH), on smears.
(c) 2008 Wiley-Liss, Inc.