Symptom remission in first episode patients

Schizophr Res. 2008 Dec;106(2-3):281-5. doi: 10.1016/j.schres.2008.09.014. Epub 2008 Oct 16.


Recently, new remission criteria for schizophrenia has been proposed, based on low symptom severity of core symptoms (the severity criteria), which is sustained over a minimum of 6 months (time criterion). The purpose of this study was to examine, in a secondary analysis, these criteria in a cohort of 240 first episode patients with a mean follow-up of 26.4 months from the Calgary Early Psychosis Program. Eighty-eight subjects (36.7%) met both the severity criteria and time criteria for remission (in-remission group); 47 subjects (19.6%) met only the severity criteria at their most recent assessment (severity only group); 49 (20.4%) subjects had met severity criteria at one or more assessments but did not meet severity or severity and time at the most recent assessment (fluctuating group); and 56 (23.3%) did not meet remission criteria (non-remission group). Those who achieved remission had lower levels of symptoms and higher functioning at baseline and at the final follow-up assessment, improved premorbid functioning, shorter duration of untreated psychosis and increased changes in symptoms over time.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age of Onset
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Neuropsychological Tests
  • Outcome Assessment, Health Care
  • Prognosis
  • Psychiatric Status Rating Scales / statistics & numerical data*
  • Psychometrics
  • Psychotic Disorders / diagnosis*
  • Psychotic Disorders / psychology
  • Schizophrenia / diagnosis*
  • Schizophrenic Psychology*
  • Severity of Illness Index*
  • Time Factors