The role of FXR in disorders of bile acid homeostasis

Physiology (Bethesda). 2008 Oct:23:286-95. doi: 10.1152/physiol.00020.2008.

Abstract

As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bile Acids and Salts / metabolism*
  • Biliary Tract Diseases / drug therapy
  • Biliary Tract Diseases / genetics*
  • Biliary Tract Diseases / physiopathology*
  • DNA-Binding Proteins / drug effects
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Homeostasis / genetics
  • Homeostasis / physiology*
  • Humans
  • Intestines / microbiology
  • Intestines / physiology
  • Ligands
  • Liver Diseases / genetics
  • Liver Diseases / physiopathology
  • Receptors, Cytoplasmic and Nuclear / drug effects
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Transcription Factors / drug effects
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • Bile Acids and Salts
  • DNA-Binding Proteins
  • Ligands
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • farnesoid X-activated receptor