A role for Th17 cells in the immunopathogenesis of atopic dermatitis?

J Invest Dermatol. 2008 Nov;128(11):2569-2571. doi: 10.1038/jid.2008.283.

Abstract

Atopic dermatitis (AD) is a common inflammatory skin disease. Both epidermal barrier dysfunction and immunodysregulation are suggested to influence the pathogenesis of AD. AD has been considered a paradigmatic T helper cell (Th) 2-mediated disease, with a switch to a Th1 cell environment during the chronic phase of the disease. Previously unreported findings now suggest a possible role for Th17 cells as well.

Publication types

  • Comment

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology
  • Dermatitis, Atopic / etiology*
  • Dermatitis, Atopic / immunology*
  • Disease Progression
  • Humans
  • Interleukin-17 / metabolism*
  • Severity of Illness Index
  • T-Lymphocytes, Helper-Inducer / metabolism*
  • Th1 Cells / metabolism
  • Th2 Cells / metabolism

Substances

  • Interleukin-17