Epigenome dynamics: a quantitative genetics perspective

Nat Rev Genet. 2008 Nov;9(11):883-90. doi: 10.1038/nrg2467.


Classically, quantitative geneticists have envisioned DNA sequence variants as the only source of heritable phenotypes. This view should be revised in light of accumulating evidence for widespread epigenetic variation in natural and experimental populations. Here we argue that it is timely to consider novel experimental strategies and analysis models to capture the potentially dynamic interplay between chromatin and DNA sequence factors in complex traits.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Base Sequence
  • Chromatin / genetics
  • Chromatin / physiology*
  • Chromatin Immunoprecipitation / methods
  • Epigenesis, Genetic / genetics*
  • Evolution, Molecular*
  • Genetic Variation*
  • Genetics, Population*
  • Phenotype*
  • Quantitative Trait Loci


  • Chromatin