IFNgamma signaling-does it mean JAK-STAT?

Cytokine Growth Factor Rev. Oct-Dec 2008;19(5-6):383-94. doi: 10.1016/j.cytogfr.2008.08.004. Epub 2008 Oct 16.


The molecular pathways involved in the cellular response to interferon (IFN)gamma have been the focus of much research effort due to their importance in host defense against infection and disease, as well as its potential as a therapeutic agent. The discovery of the JAK-STAT signaling pathway greatly enhanced our understanding of the mechanism of IFNgamma-mediated gene transcription. However, in recent years it has become apparent that other pathways, including MAP kinase, PI3-K, CaMKII and NF-kappaB, either co-operate with or act in parallel to JAK-STAT signaling to regulate the many facets of IFNgamma biology in a gene- and cell type-specific manner. The complex interactions between JAK/STAT and alternate pathways and the impact of these signaling networks on the biological responses to IFNgamma are beginning to be understood. This review summarizes and appraises current advances in our understanding of these complex interactions, their specificity and proposed biological outcomes.

Publication types

  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Protein-beta / physiology
  • Cell Adhesion / physiology
  • Cell Cycle / drug effects
  • Extracellular Signal-Regulated MAP Kinases / physiology
  • Humans
  • Interferon Regulatory Factors / physiology
  • Interferon-gamma / physiology*
  • Janus Kinases / metabolism*
  • NF-kappa B / physiology
  • Nuclear Proteins / physiology
  • Phosphatidylinositol 3-Kinases / physiology
  • Protein Kinase C / physiology
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogene Proteins c-akt / physiology
  • Receptors, Interferon / metabolism
  • STAT1 Transcription Factor / metabolism*
  • STAT3 Transcription Factor / physiology
  • STAT5 Transcription Factor / physiology
  • Signal Transduction / physiology*
  • Trans-Activators / physiology
  • Transcription Factor AP-1 / physiology


  • CCAAT-Enhancer-Binding Protein-beta
  • Interferon Regulatory Factors
  • MHC class II transactivator protein
  • NF-kappa B
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Receptors, Interferon
  • STAT1 Transcription Factor
  • STAT3 Transcription Factor
  • STAT5 Transcription Factor
  • Trans-Activators
  • Transcription Factor AP-1
  • proto-oncogene protein Spi-1
  • interferon gamma receptor
  • Interferon-gamma
  • Phosphatidylinositol 3-Kinases
  • Janus Kinases
  • Proto-Oncogene Proteins c-akt
  • Protein Kinase C
  • Extracellular Signal-Regulated MAP Kinases