Deficiency and supplementation of PUFA in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levels

Mech Ageing Dev. 2008 Dec;129(12):759-62. doi: 10.1016/j.mad.2008.09.009. Epub 2008 Sep 25.


Levels of plasma cholesterol, particularly LDL cholesterol, increase with increasing age in humans and rodents. Feeding a fish oil-rich diet may exert hypocholesterolemic effects. The aim of this work was to examine the effects of a life-long administration of a PUFA-enriched diet and of a PUFA-deficient diet in male Sprague-Dawley rats on the age-associated increases in plasma cholesterol and triglycerides. Diet had small effects on body-weight, and had dramatic effects on liver phospholipids-fatty acids. Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats.

MeSH terms

  • Aging / blood*
  • Animals
  • Cholesterol / blood*
  • Dietary Fats, Unsaturated / administration & dosage*
  • Fatty Acids / chemistry
  • Fatty Acids / metabolism
  • Fatty Acids, Unsaturated / administration & dosage*
  • Liver / metabolism
  • Male
  • Phospholipids / chemistry
  • Phospholipids / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Triglycerides / blood


  • Dietary Fats, Unsaturated
  • Fatty Acids
  • Fatty Acids, Unsaturated
  • Phospholipids
  • Triglycerides
  • Cholesterol