Robust signaling networks of the adipose secretome

Trends Endocrinol Metab. 2009 Jan;20(1):1-7. doi: 10.1016/j.tem.2008.08.006. Epub 2008 Oct 17.


Type 2 diabetes is a prototypical complex systems disease that has a strong hereditary component and etiologic links with a sedentary lifestyle, overeating and obesity. Adipose tissue has been shown to be a central driver of type 2 diabetes progression, establishing and maintaining a chronic state of low-level inflammation. The number and diversity of identified endocrine factors from adipose tissue (adipokines) is growing rapidly. Here, I argue that a systems biology approach to understanding the robust multi-level signaling networks established by the adipose secretome will be crucial for developing efficient type 2 diabetes treatment. Recent advances in whole-genome association studies, global molecular profiling and quantitative modeling are currently fueling the emergence of this novel research strategy.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / metabolism*
  • Animals
  • Diabetes Mellitus, Type 2 / genetics
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes Mellitus, Type 2 / pathology
  • Disease Progression
  • Gene Regulatory Networks / physiology*
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism
  • Inflammation / pathology
  • Metabolic Networks and Pathways / genetics*
  • Metabolic Networks and Pathways / physiology
  • Metabolome / genetics
  • Metabolome / physiology
  • Models, Biological
  • Systems Biology / methods