Automatic detection of diabetic retinopathy exudates from non-dilated retinal images using mathematical morphology methods

Comput Med Imaging Graph. 2008 Dec;32(8):720-7. doi: 10.1016/j.compmedimag.2008.08.009. Epub 2008 Oct 18.

Abstract

Diabetic retinopathy is a complication of diabetes that is caused by changes in the blood vessels of the retina. The symptoms can blur or distort the patient's vision and are a main cause of blindness. Exudates are one of the primary signs of diabetic retinopathy. Detection of exudates by ophthalmologists normally requires pupil dilation using a chemical solution which takes time and affects patients. This paper investigates and proposes a set of optimally adjusted morphological operators to be used for exudate detection on diabetic retinopathy patients' non-dilated pupil and low-contrast images. These automatically detected exudates are validated by comparing with expert ophthalmologists' hand-drawn ground-truths. The results are successful and the sensitivity and specificity for our exudate detection is 80% and 99.5%, respectively.

MeSH terms

  • Diabetic Retinopathy / diagnosis*
  • Diabetic Retinopathy / pathology
  • Exudates and Transudates*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Models, Anatomic*
  • Pattern Recognition, Automated / methods
  • Photomicrography / methods*
  • Reference Values
  • Retina / pathology
  • Retinal Vessels / pathology
  • Sensitivity and Specificity
  • Work Simplification