Platelets, coagulation, and fibrinolysis in sickle cell disease: their possible role in vascular occlusion

Blood Coagul Fibrinolysis. 1991 Apr;2(2):341-53. doi: 10.1097/00001721-199104000-00018.


Recent evidence suggests that sickle cell disease (SCD) can be considered a hypercoagulable state, in which both platelet activation and thrombin generation are abnormally increased. Although thrombosis is now known to play an important role in at least one of the vasocclusive complications of SCD, namely stroke, the significance of hypercoagulability in the pathogenesis of vascular occlusion in SCD remains unclear. This review summarizes current evidence regarding platelet, coagulation, and fibrinolytic abnormalities in SCD and their possible role in vascular occlusion. Potential implications for therapy are also discussed.

Publication types

  • Review

MeSH terms

  • Anemia, Sickle Cell / blood*
  • Anemia, Sickle Cell / complications
  • Anemia, Sickle Cell / drug therapy
  • Blood Coagulation*
  • Blood Platelets / physiology*
  • Erythrocytes, Abnormal / physiology
  • Fibrinolysis*
  • Humans
  • Vascular Diseases / etiology*
  • Vascular Diseases / prevention & control