Abstract
Enzymatic kinetic resolution of aliphatic and benzylic amines leading to (S)-amides was achieved by using alkaline protease as the catalyst and N-octanoyl glycine trifluoroethyl ester as the acyl donor; enantioselectivity ranged between 4 to 244, while reaction times were dramatically shortened and ranged between 15 min to 6 h.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / metabolism*
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Biocatalysis*
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Esters / chemistry
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Glycine / analogs & derivatives*
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Glycine / metabolism*
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Kinetics
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Serine Endopeptidases / chemistry
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Serine Endopeptidases / metabolism*
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Stereoisomerism
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Substrate Specificity
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Temperature
Substances
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Amines
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Esters
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Serine Endopeptidases
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Glycine