Insulin producing cells derived from embryonic stem cells: are we there yet?

J Cell Physiol. 2009 Feb;218(2):256-63. doi: 10.1002/jcp.21615.


Derivation of insulin producing cells (IPCs) from embryonic stem (ES) cells provides a potentially innovative form of treatment for type 1 diabetes. Here, we discuss the current state of the art, unique challenges, and future directions on generating IPCs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Embryonic Stem Cells / cytology*
  • Endoderm / cytology
  • Humans
  • Insulin-Secreting Cells / cytology*
  • Insulin-Secreting Cells / transplantation
  • Organ Specificity
  • Transcription Factors / metabolism


  • Transcription Factors