Biological activity of dilute isoproterenol solution stored for long periods in plastic bags

Am J Hosp Pharm. 1977 Jul;34(7):709-12.

Abstract

The effect of long-term storage in polyvinyl chloride bags on the biological activity and the chemical stability of isoproterenol was studied. A freshly prepared solution of isoproterenol, isoproterenol solution stored for six months and isoproterenol stored for 30 months were infused into the coronary circulation of 14 isolated rabbit hearts; heart rates were determined. Spectrophotometric studies to determine stability at various pH levels were also done. Aging of the solutions at pH 4 and at a concentration of 4 microgram/ml caused no significant impairment of their potency. Solutions above pH 6 were unstable.

MeSH terms

  • Animals
  • Drug Packaging*
  • Drug Stability
  • Drug Storage
  • Female
  • Heart Rate / drug effects
  • Hydrogen-Ion Concentration
  • In Vitro Techniques
  • Isoproterenol / analysis
  • Isoproterenol / pharmacology*
  • Male
  • Polyvinyl Chloride*
  • Polyvinyls*
  • Rabbits
  • Solutions / analysis
  • Spectrophotometry, Ultraviolet
  • Time Factors

Substances

  • Polyvinyls
  • Solutions
  • Polyvinyl Chloride
  • Isoproterenol