A cytotoxic substance from Sangre de Grado

Chem Pharm Bull (Tokyo). 1991 Apr;39(4):1041-2. doi: 10.1248/cpb.39.1041.


Taspine has been isolated as a cytotoxic substance from Sangre de Grado, sap of Croton palanostigma (Euphorbiaceae), by bioassay guided fractionation. The cytotoxicity (IC50) of taspine was found to be 0.39 microgram/ml against KB cells and 0.17 microgram/ml against V-79 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Plants, Medicinal / analysis*
  • Tumor Cells, Cultured / drug effects


  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • taspine