RNA Folding and Ribosome Assembly

Curr Opin Chem Biol. 2008 Dec;12(6):667-73. doi: 10.1016/j.cbpa.2008.09.024. Epub 2008 Oct 18.


Ribosome synthesis is a tightly regulated process that is crucial for cell survival. Chemical footprinting, mass spectrometry, and cryo-electron microscopy are revealing how these complex cellular machines are assembled. Rapid folding of the rRNA provides a platform for protein-induced assembly of the bacterial 30S ribosome. Multiple assembly pathways increase the flexibility of the assembly process, while accessory factors and modification enzymes chaperone the late stages of assembly and control the quality of the mature subunits.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Enzymes / metabolism
  • Proteins / metabolism
  • RNA / chemistry*
  • RNA / metabolism*
  • RNA, Ribosomal, 16S / chemistry
  • RNA, Ribosomal, 16S / metabolism
  • Ribosome Subunits, Small, Bacterial / chemistry
  • Ribosome Subunits, Small, Bacterial / metabolism
  • Ribosomes / chemistry*
  • Ribosomes / metabolism*


  • Enzymes
  • Proteins
  • RNA, Ribosomal, 16S
  • RNA