The effect of symptom duration in epithelial ovarian cancer on prognostic factors

Arch Gynecol Obstet. 2009 Jun;279(6):797-801. doi: 10.1007/s00404-008-0814-1. Epub 2008 Oct 21.


Purpose: To assess the association between duration of symptoms and main prognostic factors of invasive epithelial ovarian cancer (EOC).

Methods: The data of all histologically confirmed EOC patients diagnosed in Israel during the period 1994-1999 (n = 1,005) were retrieved from discharge summaries and admission records. Of the 371 (36.9%) patients with known presenting symptoms, the durations of 187 (50.4%) were recorded.

Results: The most common presenting symptoms were abdominal pain (65.2%). The percentage of patients with three or more symptoms increased significantly with stage (P = 0.001). No statistically significant association between duration of symptoms and prognostic factors was found.

Conclusion: Our findings did not show an association between duration of symptoms and prognostic factors in EOC patients and may indicate that prognosis is not a function of delay in diagnosis.

MeSH terms

  • Carcinoma / diagnosis*
  • Carcinoma / genetics
  • Carcinoma / physiopathology
  • Female
  • Genes, BRCA1*
  • Genes, BRCA2*
  • Humans
  • Mutation
  • Neoplasm Staging
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / genetics
  • Ovarian Neoplasms / physiopathology
  • Prognosis
  • Retrospective Studies
  • Time Factors