Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 30 (11-12), 1172-84

Dysfunction of the Ubiquitin-Proteasome System in Multiple Disease Conditions: Therapeutic Approaches

Affiliations
Review

Dysfunction of the Ubiquitin-Proteasome System in Multiple Disease Conditions: Therapeutic Approaches

Subhankar Paul. Bioessays.

Abstract

The ubiquitin-proteasome system (UPS) is the major proteolytic pathway that degrades intracellular proteins in a regulated manner. Deregulation of the UPS has been implicated in the pathogenesis of many neurodegenerative disorders like Alzheimer's disease, Parkinson's diseases, Huntington disease, Prion-like lethal disorders, in the pathogenesis of several genetic diseases including cystic fibrosis, Angelman's syndrome and Liddle syndrome and in many cancers. Multiple lines of evidence have already proved that UPS has the potential to be an exciting novel therapeutic target for the treatment of these diseases. Here I review how aberrant functions of various genes have implicated UPS in many human disorders including neurodegeneration and cancers. I also discuss the finding that some proteasome inhibitors possess a therapeutic potential as drugs against many such diseases.

Similar articles

See all similar articles

Cited by 44 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback