Automated assessment of ovarian follicles using a novel three-dimensional ultrasound software

Fertil Steril. 2009 Nov;92(5):1562-8. doi: 10.1016/j.fertnstert.2008.08.102. Epub 2008 Oct 19.


Objective: To evaluate the accuracy, efficiency, and applicability of a new automated method of follicular assessment.

Design: Retrospective review of three-dimensional ultrasonographic ovarian volumes.

Setting: Academic center.

Patient(s): Three-dimensional ovarian volumes from patients undergoing IVF.

Intervention(s): Three-dimensional volumes of gonadotropin-stimulated ovaries and simulated ovarian follicles (SOFs) of known volume were evaluated with the new automated follicular assessment software (SonoAVC).

Main outcome measure(s): [1] Maximum absolute error for the SonoAVC in assessing the volumes of the SOFs; [2] correlations between the automated and manual follicular measurements; [3] time required to analyze all of the follicles in a given ovarian volume.

Result(s): The SOF of 4, 6, and 10 mm were evaluated. The SonoAVC's maximum absolute error for the volumes of the 4, 6, and 10 mm SOFs was 0 (0%), 0.01 (8.3%), and 0.02 (3.8%) cc, respectively. Three hundred forty-seven follicles, ranging in diameter from 2.3-32 mm, were evaluated. The correlation coefficient for the SonoAVC-generated relaxed follicular diameter and the manual measured mean follicular diameter was 0.99. The time required to analyze all of the follicles in a given ovarian volume for the automated and manual method was 133 versus 361 seconds, respectively.

Conclusion(s): The SonoAVC proved to be a very accurate and efficient way to measure ovarian follicles. The measurements obtained by the SonoAVC correlated extremely well with the manual measurements we obtained.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Efficiency
  • Electronic Data Processing / methods
  • Female
  • Fertilization in Vitro
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Infertility, Female / diagnostic imaging
  • Infertility, Female / pathology
  • Infertility, Female / therapy
  • Organ Size / physiology
  • Ovarian Follicle / diagnostic imaging*
  • Ovarian Follicle / pathology
  • Ovary / diagnostic imaging
  • Ovulation Induction / methods
  • Pregnancy
  • Sensitivity and Specificity
  • Software*
  • Ultrasonography