Glaucoma alters the expression of NGF and NGF receptors in visual cortex and geniculate nucleus of rats: effect of eye NGF application

Vision Res. 2009 Jan;49(1):54-63. doi: 10.1016/j.visres.2008.09.024. Epub 2008 Nov 11.


We investigated the effect of glaucoma (GL) on nerve growth factor (NGF) presence in two brain visual areas. Rats with elevated intraocular pressure (EIOP), induced by hypertonic saline injection in the episcleral vein, were treated with eye topical application of saline or NGF. Rats were subsequently sacrificed, and brain tissues were used for immunohistochemical, biochemical, and molecular analyses. We found that GL alters the basal level of NGF and NGF receptors in brain visual centers and that NGF eye application normalized these deficits. These findings demonstrate that the reduced presence of NGF can arise due to degenerative events in retinal and brain visual areas.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Animals
  • Blotting, Western / methods
  • Geniculate Bodies / chemistry
  • Geniculate Bodies / metabolism*
  • Glaucoma / metabolism*
  • Immunohistochemistry
  • Male
  • Models, Animal
  • Nerve Growth Factor / analysis
  • Nerve Growth Factor / metabolism*
  • Nerve Growth Factor / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, trkA / analysis
  • Receptor, trkA / metabolism
  • Receptors, Nerve Growth Factor / analysis
  • Receptors, Nerve Growth Factor / metabolism*
  • Visual Cortex / chemistry
  • Visual Cortex / metabolism*


  • Receptors, Nerve Growth Factor
  • Nerve Growth Factor
  • Receptor, trkA