Reorganization of the nuclear envelope during open mitosis

Curr Opin Cell Biol. 2008 Dec;20(6):669-77. doi: 10.1016/ Epub 2008 Nov 2.


The nuclear envelope (NE) provides a selective barrier between the nuclear interior and the cytoplasm and constitutes a central component of intracellular architecture. During mitosis in metazoa, the NE breaks down leading to the complete mixing of the nuclear content with the cytosol. Interestingly, many NE components actively participate in mitotic progression. After chromosome segregation, the NE is reassembled around decondensing chromatin and the nuclear compartment is reestablished in the daughter cells. Here, we summarize recent progress in deciphering the molecular mechanisms underlying NE dynamics during cell division.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cell Nucleus / metabolism*
  • Cytoplasm / metabolism
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Mitosis / physiology*
  • Models, Biological
  • Nuclear Envelope / metabolism*
  • Nuclear Pore Complex Proteins / metabolism


  • Nuclear Pore Complex Proteins