Estrogen receptor 2 polymorphism and carotid intima-media thickness

Genet Test. 2008 Dec;12(4):537-40. doi: 10.1089/gte.2008.0034.


Aims: The present study was designed to investigate the effects of estrogen receptor 2 gene (ESR2) rs1256049 polymorphism to carotid artery intima-media thickness (CIMT), as part of the Cardiovascular Risk in Young Finns Study.

Results: The frequencies of ESR2 genotypes G/G, G/A, and A/A were 85.1%, 14.3%, and 0.7%, respectively, in the whole study population (n = 2211). Compared with subjects with genotype GG, those with the A allele had higher mean CIMT (p = 0.004) and maximal CIMT (p = 0.005).

Conclusions: In a Finnish population, the ESR2 rs1256049 polymorphism A allele is associated with preclinical atherosclerosis in young adulthood. Our results and those of others also suggest that some effects of this genetic variation may be population specific.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Atherosclerosis / diagnostic imaging
  • Atherosclerosis / genetics
  • Carotid Arteries / diagnostic imaging*
  • Estrogen Receptor beta / genetics*
  • Female
  • Finland
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic*
  • Tunica Intima / diagnostic imaging
  • Ultrasonography


  • Estrogen Receptor beta